Preferred Label : Non-Histone Chromosomal Protein HMG-14;
NCIt synonyms : HMG 14; HMG14; High Mobility Group Nucleosomal Binding Protein 1; High-Mobility Group (Nonhistone Chromosomal) Protein 14; High Mobility Group Nucleosome-Binding Domain-Containing Protein 1; Nonhistone Chromosomal Protein HMG14; HMGN1; High Mobility Group Protein 14; High-Mobility Group Nucleosome Binding Domain 1; HMG-14; HMGN1 Protein; Nonhistone Chromosomal Protein HMG-14; High-Mobility Group Nucleosome Binding 1; Chromosomal Protein, Nonhistone, HMG14;
NCIt definition : Non-histone chromosomal protein HMG-14 (100 aa, 11 kDa) is encoded by the human HMGN1
gene. This protein plays a role in the regulation of DNA/histone interactions.;
NCIt note : Non-histone chromosomal protein known to specifically associate with the nucleosome
core. This protein unfolds the higher order chromatin structure thereby facilitating
access to the underlying DNA sequence and facilitating the orderly progression of
various DNA-dependent activities in the context of chromatin. The protein actively
shuttles between the nucleus and the cytoplasm, in a cell-cycle dependent manner.
(NCI IRP summary) HMGN1 enhances the transcriptional potential of chromatin when incorporated
into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two
molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA
sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the
structure of the nucleosome core without stabilizing the higher order chromatin structure.
By modifying the structure of nucleosomes, the proteins affect the local structure
of the chromatin fiber leading to an increase in the rate of transcriptional elongation
but not initiation. (Semin Cell Biol 1995; 6:247-55.); Non-histone chromosomal protein known to specifically associate with the nucleosome
core. This protein unfolds the higher order chromatin structure thereby facilitating
access to the underlying DNA sequence and facilitating the orderly progression of
various DNA-dependent activities in the context of chromatin. The protein actively
shuttles between the nucleus and the cytoplasm, in a cell-cycle dependent manner.
(NCI IRP summary);
Origin ID : C19934;
UMLS CUI : C5441585;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
