Preferred Label : Nucleosome Binding Domain;
NCIt synonyms : NBD;
NCIt definition : The Nucleosomal Binding Domain anchors HMG-14 and HMG-17, two canonical HMG proteins,
to nucleosomes. HMG-14 and HMG-17 are the only nuclear proteins known to specifically
recognize the genetic structure of the 146-bp nucleosome, i.e., the building block
of the chromatin fiber. Although the target of HMG-14/-17 is the nucleosome, the main
function of these proteins is to change the architecture of the higher-order chromatin
structure. These changes are mediated through the C-terminal region of the proteins.
The nucleosomal binding domain anchors these HMG proteins to the nucleosome cores
to facilitate HMG-14/-17-dependent changes in chromatin structure.;
Origin ID : C13745;
UMLS CUI : C1518456;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
