" /> Non-Histone Chromosomal Protein HMG-17 - CISMeF





Preferred Label : Non-Histone Chromosomal Protein HMG-17;

NCIt synonyms : MGC5629; High-Mobility Group Nucleosome Binding Domain 2; Chromosomal Protein, Nonhistone, HMG17; High-Mobility Group Nucleosomal Binding Domain 2; High Mobility Group Protein 17; HMG-17; High Mobility Group Nucleosome-Binding Domain-Containing Protein 2; HMGN2; High-Mobility Group Nucleosomal Binding Domain; Nonhistone Chromosomal Protein HMG-17; HMG17; High Mobility Group Protein N2; Nonhistone Chromosomal Protein HMG17; Nonhistone Chromosomal Protein HMG1; High Mobility Group Nucleosomal Binding Protein 2; High-Mobility Group (Nonhistone Chromosomal) Protein 17; HMGN2 Protein;

NCIt definition : Non-histone chromosomal protein HMG-17 (90 aa, 9 kDa) is encoded by the human HMGN2 gene. This protein is involved in the reorganization of chromatin.;

NCIt note : HMGN2 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN2 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995; 6:247-55.);

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12/05/2024


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