NCIt synonyms : High Mobility Group A Gene Family;
NCIt definition : Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes
ranging from chromosome and chromatin mechanics to transcription factors that regulate
gene expression. Hence, they influence diverse biological processes including cell
growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks
that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression
and metastasis when overexpressed. High constitutive HMGA expression is consistently
observed in cancers, with increasing concentrations being correlated with increasing
malignancy. (NCI);
Semantic type(s)