High-Mobility Group Protein HMGI-C

Preferred Label : High-Mobility Group Protein HMGI-C;

NCIt synonyms : HMGI-C; HMGIC; BABL; LIPO; High Mobility Group Protein HMGIC Breakpoint Associated with Benign Lipoma; HMGA2; HMGA2 Protein; High Mobility Group AT-Hook 2; High Mobility Group Protein Isoform I-C; High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C;

NCIt definition : High mobility group protein HMGI-C (109 aa, 12 kDa) is encoded by the human HMGA2 gene. This protein is involved in the regulation of both mitosis and gene transcription.;

NCIt note : HMGA2 is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. The expression of the gene is cell-cycle regulated. It is likely that the HMGA2 protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGA2 binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (Int J Biochem Cell Biol 1998; 30:761-6.);

NCI Metathesaurus CUI : CL963585;

Details

Origin ID

C20324;

UMLS CUI

C4742454;

Currated CISMeF NLP mapping
- HMGA2 protein [MeSH concept]
- hmga2 protein [MeSH Descriptor]
OMIM relation
- High mobility group at-hook 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HMGA2 protein [MeSH concept]
- HMGA2 protein, human [MeSH Supplementary Concept]
- hmga2 protein [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HMGA2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Nuclear Protein [NCIt concept]
- Phosphoprotein [NCIt concept]
gene_product_has_chemical_classification
- HMGA Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- AT Hook Motif [NCIt concept]
gene_product_malfunction_associated_with_disease
- Lipoma [NCIt concept]
- Obesity [NCIt concept]
- Uterine Corpus Leiomyoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Adipogenesis [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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