Preferred Label : Atherosclerosis susceptibility;
Symbol : ATHS;
CISMeF acronym : ALP; ATHS;
Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : Atherogenic lipoprotein phenotype; ALP;
Description : The atherogenic lipoprotein phenotype (ALP) is a common heritable trait characterized
by a preponderance of small, dense low density lipoprotein (LDL) particles (subclass
pattern B), increased levels of triglyceride-rich lipoproteins, reduction in high
density lipoprotein, and a 3-fold increased risk of myocardial infarction (summary
by Nishina et al., 1992). The so-called atherogenic lipoprotein phenotype was shown
by Austin et al. (1988) to be independently associated with an increased risk for
coronary artery disease. Allayee et al. (1998) concluded, furthermore, that there
is a genetically based association between familial combined hyperlipidemia (FCHL;
144250) and small, dense LDL particles and that the genetic determinants for LDL particle
size are shared, at least in part, among FCHL families and the more general population
at risk for coronary artery disease. Juo et al. (1998) concluded from a bivariate
segregation analysis of small, dense LDL particles and elevated apolipoprotein B levels
(APOB; 107730), which are commonly found together in members of FCHL families, that
the 2 traits share a common major gene plus individual polygenic components. The common
major gene was estimated to explain 37% of the variance of adjusted LDL particle size
and 23% of the variance of adjusted apoB levels.;
Inheritance : Autosomal dominant; ? same as LDLR;
Prefixed ID : %108725;
Origin ID : 108725;
UMLS CUI : C1531719;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- HPO term(s)
- Semantic type(s)
- UMLS correspondences (same concept)
