SLPI wt Allele

Preferred Label : SLPI wt Allele;

NCIt synonyms : SLPIa; ALK1; BLPI; HUSI-I; ALP; Secretory Leukocyte Protease Inhibitor (Antileukoproteinase) wt Allele; HUSI;

NCIt definition : Human SLPI wild-type allele is located within 20q12 and is approximately 2 kb in length. This allele, which encodes antileukoproteinase 1 protein, plays a role in the protection of epithelial tissues from degradation by serine proteases. The SLPI gene is overexpressed in certain types of cancer such as non-small cell lung carcinomas and ovarian carcinomas.;

NCIt note : The SLPI gene may be involved in the prevention of elastase-mediated damage to oral and other mucosal tissues.;

GenBank Accession Number : NM_003064;

Details

Origin ID

C51411;

UMLS CUI

C1706468;

False automatic mappings
- Atherosclerosis susceptibility [OMIM Phenotype]
OMIM relation
- Secretory leukocyte protease inhibitor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 20q12 [NCIt concept]
gene_is_biomarker_of
- Malignant Ovarian Neoplasm [NCIt concept]
gene_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_is_element_in_pathway
- Wound Repair Pathway [NCIt concept]
gene_plays_role_in_process
- Enzyme Inhibition [NCIt concept]
- Immune Response Process [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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