" /> PHD Finger - CISMeF





Preferred Label : PHD Finger;

NCIt synonyms : Plant Homeodomain (PHD) Type Zinc Finger; PHD-Finger; PHD Finger Domain; C4HC3 Zinc Finger; PHD Finger Motif;

NCIt definition : A C4HC3 zinc-finger-like motif, the PHD finger is found in nuclear proteins thought involved in chromatin-mediated transcriptional regulation. Single or multiple fingers are found. A specific function is not yet known, but it could be involved in protein-protein interactions important for assembly/activity of multi-component transcriptional regulatory complexes. In CBP it is an integral part of the acetyltransferase enzymatic core domain and contributes to CBP transcriptional activity. PHD fingers fold into an interleaved Zn-finger chelating two Zn ions in an atypical cross-braced conformation also shared by the FYVE and RING fingers; the zinc sites are located at opposite ends of a beta-sheet. Surrounding loops vary significantly in length and sequence between these three domains. (NCI);

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11/05/2024


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