Nuclear Body Protein SP140

Preferred Label : Nuclear Body Protein SP140;

NCIt synonyms : Speckled 140 kDa; SP140; Nuclear Autoantigen Sp-140; Lymphoid-Restricted Homolog of Sp100; Lymphoid-Restricted SP100 Homolog; LYSp100;

NCIt definition : Nuclear body protein SP140 (867 aa, 98 kDa) is encoded by the human SP140 gene. This protein may play a role in the activation of gene expression in leukocytes.;

NCIt note : Nuclear body protein SP140 is the target of autoantibodies in patients with primary biliary cirrhosis. (UniProt);

Details

Origin ID

C150323;

UMLS CUI

C0531920;

Automatic exact mappings (from CISMeF team)
- Nuclear body protein sp140 [OMIM gene]
- SP140 nuclear body protein [HGNC gene]
OMIM relation
- Nuclear body protein sp140 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- SP140 protein, human [MeSH concept]
- SP140 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SP140 Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Leukocyte [NCIt concept]
- Splenic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Bromodomain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- PHD Finger [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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