Preferred Label : PHD Zinc Fingers;
MeSH definition : Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized
by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates
binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with
a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur
in many proteins that function in chromatin-mediated gene expression and EPIGENETICS
such as POLYCOMB-GROUP PROTEINS.;
MeSH synonym : Finger, PHD Zinc; Fingers, PHD Zinc; Zinc Finger, PHD; Zinc Fingers, PHD; PHD Fingers; Finger, PHD; Fingers, PHD; PHD Finger; PHD Motifs; PHD Domains; Domain, PHD; Domains, PHD; PHD Domain; PHD Zinc Finger; PHD Finger Domain; Domain, PHD Finger; Domains, PHD Finger; Finger Domain, PHD; Finger Domains, PHD; PHD Finger Domains; PHD Motif; Motif, PHD; Motifs, PHD;
Origin ID : D000075925;
UMLS CUI : C4319810;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- Record concept(s)
- See also
- Semantic type(s)
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized
by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates
binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with
a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur
in many proteins that function in chromatin-mediated gene expression and EPIGENETICS
such as POLYCOMB-GROUP PROTEINS.
