MeSH definition : ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal
ATP-binding and helicase domains. It functions in the regulation of gene transcription
and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which
causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change
its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation
at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL
RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).;
ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal
ATP-binding and helicase domains. It functions in the regulation of gene transcription
and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which
causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change
its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation
at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL
RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
Allowable qualifiers