Kinetochore Protein NDC80 Homolog

Preferred Label : Kinetochore Protein NDC80 Homolog;

NCIt synonyms : HsHec1; NDC80 Kinetochore Complex Component Homolog; Kinetochore Protein Hec1; Kinetochore-Associated Protein 2; Highly Expressed in Cancer Protein; NDC80; Retinoblastoma-Associated Protein HEC; Hec1;

NCIt definition : Kinetochore protein NDC80 homolog (642 aa, 74 kDa) is encoded by the human NDC80 gene. This protein plays a role in the attachment of mitotic spindle microtubules to the kinetochore.;

Details

Origin ID

C152016;

UMLS CUI

C1438393;

Automatic exact mappings (from CISMeF team)
- Ndc80 kinetochore complex component [OMIM gene]
OMIM relation
- Ndc80 kinetochore complex component [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NDC80 protein, human [MeSH concept]
- NDC80 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- NDC80 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
gene_product_is_element_in_pathway
- Aurora B Signaling Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Chromosome Segregation [NCIt concept]
- Metaphase Process [NCIt concept]
- Microtubule Process [NCIt concept]
- Mitotic/Spindle Checkpoint [NCIt concept]
- Positive Regulation of Mitosis [NCIt concept]
is_target
- Hec1/Nek2 Inhibitor T-1101 Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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