Mitotic/Spindle Checkpoint

Preferred Label : Mitotic/Spindle Checkpoint;

NCIt synonyms : Mitosis Checkpoint; Mitotic Checkpoint; Mitotic Spindle Checkpoint;

NCIt definition : The mitotic/spindle checkpoint ensures that all replicated chromatids are properly connected to opposing spindle poles before separation (anaphase) can begin. The proteins responsible for this form a complex on the kinetochores.;

Details

Origin ID

C21492;

UMLS CUI

C1155750;

Automatic exact mappings (from CISMeF team)
- M phase cell cycle checkpoints [MeSH Descriptor]
- mitotic cell cycle checkpoint [GO term]
- mitotic spindle checkpoint signaling [GO term]
Currated CISMeF NLP mapping
- mitotic checkpoints [MeSH concept]
- mitotic spindle checkpoints [MeSH concept]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- mitotic spindle checkpoint signaling [GO term]
- mitotic spindle checkpoints [MeSH concept]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Mitogen [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_involves_gene_product
- DNA Cross-Link Repair 1A Protein [NCIt concept]
- G2/Mitotic-Specific Cyclin-B2 [NCIt concept]
- HAUS Augmin-Like Complex Subunit 7 [NCIt concept]
- Kinetochore Protein NDC80 Homolog [NCIt concept]
- Kinetochore Scaffold 1 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2A [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2B [NCIt concept]
- Nucleoprotein TPR [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 44 [NCIt concept]
biological_process_is_part_of_process
- Cell Proliferation [NCIt concept]
- Metaphase Process [NCIt concept]
process_involves_gene
- BUB1 Gene [NCIt concept]
- BUB1 wt Allele [NCIt concept]
- BUB1B Gene [NCIt concept]
- BUB1B wt Allele [NCIt concept]
- CCNB2 Gene [NCIt concept]
- CCNB2 wt Allele [NCIt concept]
- DCLRE1A Gene [NCIt concept]
- DCLRE1A wt Allele [NCIt concept]
- HAUS7 Gene [NCIt concept]
- HAUS7 wt Allele [NCIt concept]
- KNL1 Gene [NCIt concept]
- KNL1 wt Allele [NCIt concept]
- MAD2L1 Gene [NCIt concept]
- MAD2L1 wt Allele [NCIt concept]
- MAD2L2 Gene [NCIt concept]
- MAD2L2 wt Allele [NCIt concept]
- NDC80 Gene [NCIt concept]
- NDC80 wt Allele [NCIt concept]
- TPR Gene [NCIt concept]
- TPR wt Allele [NCIt concept]
- USP44 Gene [NCIt concept]
- USP44 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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