CCNB2 wt Allele

Preferred Label : CCNB2 wt Allele;

NCIt synonyms : Cyclin B2 wt Allele;

NCIt definition : Human CCNB2 wild-type allele is located in the vicinity of 15q22.2 and is approximately 20 kb in length. This allele, which encodes G2/mitotic-specific cyclin-B2 protein, is involved in the regulation of the mitotic G2/M transition of the cell cycle. Aberrant allelic expression, resulting from different mechanisms, could contribute through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer.;

GenBank Accession Number : NM_004701;

Details

Origin ID

C49517;

UMLS CUI

C1707086;

OMIM relation
- Cyclin b2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 15: 57184612-57204536 [NCIt concept]
gene_in_chromosomal_location
- 15q21.2 [NCIt concept]
gene_is_element_in_pathway
- EFP Cell Cycle Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Mitotic/Spindle Checkpoint [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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