EFP Cell Cycle Pathway

Preferred Label : EFP Cell Cycle Pathway;

NCIt related terms : Estrogen-responsive protein Efp controls cell cycle and breast tumors growth;

Alternative definition : BIOCARTA: The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteasome. Released Cdks are now free to escape into the nucleus and promote mitotic entry. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_EfpPathway;

Details

Origin ID

C39057;

UMLS CUI

C1512114;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 14-3-3 Protein Sigma [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Cyclin-Dependent Kinase 7 [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- Estrogen Receptor [NCIt concept]
- G2/Mitotic-Specific Cyclin-B2 [NCIt concept]
pathway_has_gene_element
- CCNB2 wt Allele [NCIt concept]
- CDK7 wt Allele [NCIt concept]
- ESR1 wt Allele [NCIt concept]
- SFN wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]
- TRIM25 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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