Cyclin-Dependent Kinase 7

Preferred Label : Cyclin-Dependent Kinase 7;

NCIt synonyms : CAK1; STK1; p39 Mo15; CAK; 39 kDa Protein Kinase; TFIIH Basal Transcription Factor Complex Kinase Subunit; EC 2.7.11.22; CDK-Activating Kinase; EC 2.7.11.23; Serine/Threonine-Protein Kinase 1; Cell Division Protein Kinase 7; CDK-Activating Kinase 1; CDK7;

NCIt definition : Cyclin-dependent kinase 7 (346 aa, 39 kDa) is encoded by the human CDK7 gene. This protein is involved in the mediation of protein phosphorylation that regulates both RNA polymerase II-mediated transcription and cell cycle progression.;

Details

Origin ID

C89769;

UMLS CUI

C0255652;

Currated CISMeF NLP mapping
- Cyclin-Dependent Kinase-Activating Kinase [MeSH Descriptor]
OMIM relation
- Cyclin-dependent kinase 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK7 protein, human [MeSH Supplementary Concept]
- CDK7 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Basal Transcription Factor Gene [NCIt concept]
- CDK7 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Basal Transcription Factor Assembly Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- EFP Cell Cycle Pathway [NCIt concept]
- Nucleotide Excision Repair Pathway [NCIt concept]
- Ptc1 Regulation of Cell Cycle Pathway [NCIt concept]
- RAR and RXR Degradation Pathway [NCIt concept]
- Retinoic Acid Receptor Family-Mediated Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- TFIIH [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Repair [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Kinase Protein Phosphorylation [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- CDK7 Inhibitor Q901 [NCIt concept]
- CDK7 Inhibitor SY-5609 [NCIt concept]
- CDK7 Inhibitor TY-2699a [NCIt concept]
- CK1alpha/CDK7/CDK9 Inhibitor BTX-A51 [NCIt concept]
- Mevociclib [NCIt concept]
- Seliciclib [NCIt concept]
- Tacaciclib [NCIt concept]
- Zotiraciclib Citrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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