Mevociclib - CISMeF

Preferred Label : Mevociclib;

NCIt synonyms : CDK7 Inhibitor SY-1365;

NCIt definition : A selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic activity. Upon administration, SY-1365 binds to and inhibits CDK7, thereby inhibiting CDK7-mediated signal transduction pathways. This inhibits cell growth of CDK7-overexpressing tumor cells. CDK7, a serine/threonine kinase, plays a key role in cell proliferation; CDK7 is overexpressed in a variety of tumor cell types.;

UNII : 704LW082GI;

InChIKey : SCJNYBYSTCRPAO-LXBQGUBHSA-N;

CAS number : 1816989-16-8;

Molecule name : SY-1365;

NCI Metathesaurus CUI : CL526907;

Details

Origin ID

C139552;

UMLS CUI

C5418194;

Currated CISMeF NLP mapping
- mevociclib [MeSH Supplementary Concept]
- mevociclib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mevociclib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 7 [NCIt concept]

Keyword's position in hierarchy(ies) :

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