Cyclin-Dependent Kinase

Preferred Label : Cyclin-Dependent Kinase;

NCIt synonyms : Cyclin Dependent Kinase; CDK; Cyclin Dependent Kinase Family; Cyclin-Dependent Kinase Family;

NCIt definition : Cyclin-dependent kinases are eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.;

Details

Origin ID

C17767;

UMLS CUI

C0243045;

Automatic exact mappings (from CISMeF team)
- cyclin-dependent protein serine/threonine kinase activity [GO term]
Biochemical function of gene products
- Positive Transcription Elongation Factor B [NCIt concept]
Currated CISMeF NLP mapping
- Cyclin-Dependent kinases [MeSH Descriptor]
- Cyclin-Dependent kinases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cyclin-Dependent kinases [MeSH concept]
- Cyclin-Dependent kinases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- 7-Hydroxystaurosporine [NCIt concept]
- Alvocidib [NCIt concept]
- Alvocidib Hydrochloride [NCIt concept]
- CDK Inhibitor AT7519 [NCIt concept]
- CDK Inhibitor R547 [NCIt concept]
- CDK Inhibitor SNS-032 [NCIt concept]
- CDK2/4/6/FLT3 Inhibitor FN-1501 [NCIt concept]
- CDK7 Inhibitor LY3405105 [NCIt concept]
- CDK7 Inhibitor LY3405105 Besylate [NCIt concept]
- CDK8/19 Inhibitor RVU120 [NCIt concept]
- CDK9 Inhibitor GFH009 [NCIt concept]
- CDK9 Inhibitor PRT2527 [NCIt concept]
- Enitociclib [NCIt concept]
- Fadraciclib [NCIt concept]
- Istisociclib [NCIt concept]
- Palbociclib [NCIt concept]
- Palbociclib Isethionate [NCIt concept]
- Riviciclib [NCIt concept]
- Seliciclib [NCIt concept]
- Zemirciclib [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- 7-Hydroxystaurosporine [NCIt concept]
- Alvocidib [NCIt concept]
- Alvocidib Hydrochloride [NCIt concept]
- CDK Inhibitor AT7519 [NCIt concept]
- CDK7 Inhibitor LY3405105 [NCIt concept]
- CDK7 Inhibitor LY3405105 Besylate [NCIt concept]
- CDK8/19 Inhibitor RVU120 [NCIt concept]
- Fadraciclib [NCIt concept]

Keyword's position in hierarchy(ies) :

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