NCIt definition : A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of
cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation
of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression,
resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive
inhibitor of adenosine triphosphate activity.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent
kinase (CDK) inhibitor.;
UNII : D48MS3A6N9;
InChIKey : LGMSNQNWOCSPIK-LWHGMNCYSA-N;
CAS number : 131740-09-5;
Molecule name : L-868275; HMR 1275; HL-275; MDL-107826A; MDL 107,826A; HMR-1275; L 868275;