Preferred Label : Alvocidib Hydrochloride;
NCIt synonyms : Flavopiridol Hydrochloride; (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
Hydrochloride; Flavopiridol;
NCIt related terms : HMR 1275; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-,
hydrochloride, (-)-cis-;
NCIt definition : The hydrochloride salt form of alvocidib, a synthetic N-methylpiperidinyl chlorophenyl
flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell
cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and
by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest
and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate
activity.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent
kinase (CDK) inhibitor.;
UNII : D48MS3A6N9;
InChIKey : LGMSNQNWOCSPIK-LWHGMNCYSA-N;
CAS number : 131740-09-5;
Molecule name : L-868275; HMR 1275; HL-275; MDL-107826A; MDL 107,826A; HMR-1275; L 868275;
Chemical formula : C21H20ClNO5.HCl;
NSC code : 649890;
Codes from synonyms : CDR0000630914; NSC0649890;
Origin ID : C1571;
UMLS CUI : C2709282;
Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
