" /> Alvocidib Hydrochloride - CISMeF





Preferred Label : Alvocidib Hydrochloride;

NCIt synonyms : Flavopiridol Hydrochloride; (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride; Flavopiridol;

NCIt related terms : HMR 1275; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-;

NCIt definition : A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent kinase (CDK) inhibitor.;

UNII : D48MS3A6N9;

InChIKey : LGMSNQNWOCSPIK-LWHGMNCYSA-N;

CAS number : 131740-09-5;

Molecule name : L-868275; HMR 1275; HL-275; MDL-107826A; MDL 107,826A; HMR-1275; L 868275;

Chemical formula : C21H20ClNO5.HCl;

NSC code : 649890;

Codes from synonyms : CDR0000630914; NSC0649890;

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30/05/2025


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