Negative Regulation of G2 to M Transition

Preferred Label : Negative Regulation of G2 to M Transition;

NCIt synonyms : G2/M Arrest; G2-M Arrest;

NCIt definition : G2/M Arrest consists of cellular biochemical mechanisms, responsive to diverse conditions, that control cellular transition from the G2 to M phase of the cell cycle. Cdc2/cycB regulates this transition. During G2, Cdc2 is inactivated by Wee1 and Mt1 kinases. Activation of Cdc25 phosphatase activates Cdc2. If genome damage has occurred, activated DNA-PK/ATM/ATR kinases inactivate Cdc2/cycB by two channels. First, Cdc25 is inactivated by CHK kinases. Second, phosphorylated p53 dissociates from MDM2, is acetylated by p300/PCAF, binds DNA, and activates transcription of genes that inhibit Cdc2/cyclin (14-3-3s, GADD45, and p21Cip1).;

Details

Origin ID

C19829;

UMLS CUI

C1517345;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Mitogen [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_biological_process
- M Phase Process [NCIt concept]
biological_process_involves_gene_product
- Apoptosis-Stimulating of p53 Protein 2 [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- Membrane-Associated Tyrosine- and Threonine-Specific Cdc2-Inhibitory Kinase [NCIt concept]
biological_process_is_part_of_process
- Cell Cycle Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- G2 to M Transition Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Alvocidib [NCIt concept]
- Alvocidib Hydrochloride [NCIt concept]
- Bizelesin [NCIt concept]
- CDK Inhibitor R547 [NCIt concept]
- Docetaxel [NCIt concept]
- Folate Receptor-Targeted Vinca Alkaloid EC0489 [NCIt concept]
- Iso-fludelone [NCIt concept]
- Ixabepilone [NCIt concept]
- Oral Ixabepilone [NCIt concept]
- Paclitaxel Ceribate [NCIt concept]
- Palbociclib [NCIt concept]
- Palbociclib Isethionate [NCIt concept]
- Seliciclib [NCIt concept]
- Verubulin [NCIt concept]
- Verubulin Hydrochloride [NCIt concept]
process_involves_gene
- PKMYT1 Gene [NCIt concept]
- PKMYT1 wt Allele [NCIt concept]
- TP53BP2 Gene [NCIt concept]
- TP53BP2 wt Allele [NCIt concept]
- TRIM25 Gene [NCIt concept]
- TRIM25 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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