Paclitaxel Ceribate

Preferred Label : Paclitaxel Ceribate;

NCIt synonyms : 7beta-((2RS)-2,3-dihydroxypropoxycarbonyloxy)-1-hydroxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,10beta,13alpha-tetrayl 4,10-diacetate 2-benzoate 13-((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate);

NCIt definition : The ceribate ester form of paclitaxel, a compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to and stabilizes tubulin thereby inhibiting the disassembly of microtubules, resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (BCL2).;

UNII : B3C86E80A0;

InChIKey : HSUDWURBWSUCOB-JPHWUADUSA-N;

CAS number : 186040-50-6;

Chemical formula : C51H57NO18;

Details

Origin ID

C96934;

UMLS CUI

C3273125;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of G2 to M Transition [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients