Palbociclib Isethionate

Preferred Label : Palbociclib Isethionate;

NCIt synonyms : 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino(pyrido(2,3-d)pyrimidin-7(8h)-one mono(2-hydroxyethanesulfonate);

NCIt definition : The isethionate salt form of palbociclib, an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.;

UNII : W1NYL2IRDR;

InChIKey : LYYVFHRFIJKPOV-UHFFFAOYSA-N;

CAS number : 827022-33-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 827022-33-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PD 0332991-0054; PF-00080665-73;

Chemical formula : C24H29N7O2.C2-H6-O4-S;

Details

Origin ID

C120259;

UMLS CUI

C3896941;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Negative Regulation of G1 Phase [NCIt concept]
- Negative Regulation of G2 to M Transition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Protein Phosphorylation Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Palbociclib [NCIt concept]
has_target
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
is_salt_form_of
- Palbociclib [NCIt concept]

Keyword's position in hierarchy(ies) :

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