" /> Palbociclib Isethionate - CISMeF





Preferred Label : Palbociclib Isethionate;

NCIt synonyms : 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino(pyrido(2,3-d)pyrimidin-7(8h)-one mono(2-hydroxyethanesulfonate);

NCIt definition : The isethionate salt form of palbociclib, an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.;

UNII : W1NYL2IRDR;

InChIKey : LYYVFHRFIJKPOV-UHFFFAOYSA-N;

CAS number : 827022-33-3;

Molecule name : PD 0332991-0054; PF-00080665-73;

Chemical formula : C24H29N7O2.C2-H6-O4-S;

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08/05/2025


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