Cyclin-Dependent Kinase 6

Preferred Label : Cyclin-Dependent Kinase 6;

NCIt synonyms : EC 2.7.11.22; Serine/Threonine-Protein Kinase PLSTIRE; Cell Division Protein Kinase 6; CDK6;

NCIt definition : Cyclin-dependent kinase 6 (326 aa, 37 kDa) is encoded by the human CDK6 gene. This protein plays a role in both protein phosphorylation and cell cycle progression.;

Details

Origin ID

C97386;

UMLS CUI

C1565313;

Automatic exact mappings (from CISMeF team)
- Cyclin-Dependent kinase 6 [MeSH Descriptor]
- Cyclin-Dependent kinase 6 [MeSH concept]
- Cyclin-dependent kinase 6 [OMIM gene]
- cyclin dependent kinase 6 [ORDO Gene]
OMIM relation
- Cyclin-dependent kinase 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK6 protein, human [MeSH concept]
- CDK6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDK6 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G1 Phase Process [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Abemaciclib [NCIt concept]
- Abemaciclib Mesylate [NCIt concept]
- CDK2/4/6 Inhibitor PF-07224826 [NCIt concept]
- CDK2/4/6 Inhibitor RGT-419B [NCIt concept]
- CDK2/4/6 Inhibitor SYH2043 [NCIt concept]
- CDK2/4/6/FLT3 Inhibitor FN-1501 [NCIt concept]
- CDK4/6 Inhibitor BPI-1178 [NCIt concept]
- CDK4/6 Inhibitor BPI-16350 [NCIt concept]
- CDK4/6 Inhibitor CS3002 [NCIt concept]
- CDK4/6 Inhibitor FCN-437 [NCIt concept]
- CDK4/6 Inhibitor GLR2007 [NCIt concept]
- CDK4/6 Inhibitor HS-10342 [NCIt concept]
- CDK4/6 Inhibitor PRT3645 [NCIt concept]
- CDK4/6 Inhibitor QLS12004 [NCIt concept]
- CDK4/6 Inhibitor SPH4336 [NCIt concept]
- CDK4/6 Inhibitor TQB3303 [NCIt concept]
- CDK4/6 Inhibitor TQB3616 [NCIt concept]
- CDK4/6 Inhibitor XZP-3287 [NCIt concept]
- Dalpiciclib [NCIt concept]
- Ebvaciclib [NCIt concept]
- FLT3/CDK4/6 Inhibitor FLX925 [NCIt concept]
- Inixaciclib [NCIt concept]
- Lerociclib [NCIt concept]
- Narazaciclib [NCIt concept]
- Palbociclib [NCIt concept]
- Palbociclib Isethionate [NCIt concept]
- Ribociclib [NCIt concept]
- Ribociclib/Letrozole [NCIt concept]
- Trilaciclib [NCIt concept]
- Voruciclib [NCIt concept]

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