Preferred Label : CDK4/6 Inhibitor UCT-03-008;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and
6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6
inhibitor UCT-03-008 selectively targets and inhibits CDK4 and CDK6, which inhibits
the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase and prevents
CDK-mediated G1-S-phase transition. This leads to cell cycle arrest, the induction
of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine
kinases that are important regulators of cell cycle progression and cellular proliferation
and are upregulated in many tumor cell types.;
Molecule name : UCT-03-008; UCT 03-008;
NCI Metathesaurus CUI : CL1773727;
Origin ID : C185428;
UMLS CUI : C5666996;
Semantic type(s)
- concept_is_in_subset
- has_target
