Cyclin-Dependent Kinase 4

Preferred Label : Cyclin-Dependent Kinase 4;

NCIt synonyms : CDK4; Cyclin-Dependent Kinase-4; PSK-J3; Cyclin Dependent Kinase 4; CDK4 Protein; EC 2.7.11.22; Cell Division Protein Kinase 4;

NCIt definition : Cyclin-dependent kinase 4 (303 aa, 34 kDa) is encoded by the human CDK4 gene. This protein may be involved in cell cycle regulation.;

NCIt note : A serine/threonine protein kinase involved in cell cycle control, Cdk4 may complex with D-type G1 Cyclins and belongs to the CDC2/CDKX subfamily. CDK4/CDK6 phosphorylates Rb in early G1, displacing histone deacetylase and blocking transcriptional repression. CDK4 is inhibited by p16 (Cyclin-Dependent Kinase Inhibitor-2).;

Details

Origin ID

C17680;

UMLS CUI

C1527860;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase 4 [MeSH Descriptor]
- Cyclin-Dependent kinase 4 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK4 protein, human [MeSH concept]
- CDK4 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDK4 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_product_malfunction_associated_with_disease
- Melanoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Abemaciclib [NCIt concept]
- Abemaciclib Mesylate [NCIt concept]
- CDK Inhibitor R547 [NCIt concept]
- CDK1/2/4 Inhibitor AG-024322 [NCIt concept]
- CDK2/4/6 Inhibitor PF-07224826 [NCIt concept]
- CDK2/4/6 Inhibitor RGT-419B [NCIt concept]
- CDK2/4/6 Inhibitor SYH2043 [NCIt concept]
- CDK2/4/6/FLT3 Inhibitor FN-1501 [NCIt concept]
- CDK4 Inhibitor BGB-43395 [NCIt concept]
- CDK4 Inhibitor P1446A-05 [NCIt concept]
- CDK4 Inhibitor PF-07220060 [NCIt concept]
- CDK4/6 Inhibitor BPI-1178 [NCIt concept]
- CDK4/6 Inhibitor BPI-16350 [NCIt concept]
- CDK4/6 Inhibitor CS3002 [NCIt concept]
- CDK4/6 Inhibitor FCN-437 [NCIt concept]
- CDK4/6 Inhibitor GLR2007 [NCIt concept]
- CDK4/6 Inhibitor HS-10342 [NCIt concept]
- CDK4/6 Inhibitor PRT3645 [NCIt concept]
- CDK4/6 Inhibitor QLS12004 [NCIt concept]
- CDK4/6 Inhibitor SPH4336 [NCIt concept]
- CDK4/6 Inhibitor TQB3303 [NCIt concept]
- CDK4/6 Inhibitor TQB3616 [NCIt concept]
- CDK4/6 Inhibitor XZP-3287 [NCIt concept]
- Dalpiciclib [NCIt concept]
- Ebvaciclib [NCIt concept]
- FLT3/CDK4/6 Inhibitor FLX925 [NCIt concept]
- Inixaciclib [NCIt concept]
- Lerociclib [NCIt concept]
- Narazaciclib [NCIt concept]
- Palbociclib [NCIt concept]
- Palbociclib Isethionate [NCIt concept]
- Ribociclib [NCIt concept]
- Ribociclib/Letrozole [NCIt concept]
- Riviciclib [NCIt concept]
- Riviciclib Hydrochloride [NCIt concept]
- Roniciclib [NCIt concept]
- Trilaciclib [NCIt concept]
- Voruciclib [NCIt concept]

Keyword's position in hierarchy(ies) :

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