Ribociclib - CISMeF

Preferred Label : Ribociclib;

NCIt synonyms : 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;

NCIt definition : An orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.;

UNII : TK8ERE8P56;

InChIKey : RHXHGRAEPCAFML-UHFFFAOYSA-N;

CAS number : 1211441-98-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1211441-98-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Kisqali;

Molecule name : LEE-011;

Codes from synonyms : 441;

Details

Origin ID

C95701;

UMLS CUI

C4045494;

Automatic exact mappings (from CISMeF team)
- Ribociclib [ICD-11 Extension code]
- ribociclib [ATC Code]
Currated CISMeF NLP mapping
- Ribociclib (substance) [SNOMED CT concept]
- ribociclib [MeSH Supplementary Concept]
- ribociclib [MeSH concept]
See also inter- (CISMeF)
- Product containing ribociclib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing ribociclib (medicinal product) [SNOMED CT concept]
- Ribociclib (substance) [SNOMED CT concept]
- ribociclib [MeSH Supplementary Concept]
- ribociclib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Ribociclib Succinate [NCIt concept]
has_target
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
is_component_of_chemotherapy_regimen
- Anastrozole/Ribociclib Regimen [NCIt concept]
- Exemestane/Ribociclib Regimen [NCIt concept]
- Fulvestrant/Ribociclib Regimen [NCIt concept]
- Letrozole/Ribociclib Regimen [NCIt concept]
- Ribociclib/Tamoxifen Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Ribociclib Succinate [NCIt concept]

Keyword's position in hierarchy(ies) :

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