Preferred Label : Ribociclib;
NCIt synonyms : 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;
NCIt definition : An orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with
antineoplastic activity. Upon oral administration, ribociclib specifically targets,
binds to and inhibits CDK4 and CDK6. This inhibits the cyclin D1/CDK4 and cyclin D3/CDK6
cell cycle pathway, which inhibits phosphorylation of the retinoblastoma (Rb) protein.
Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby
arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting
cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer,
causes cell cycle dysregulation.;
UNII : TK8ERE8P56;
InChIKey : RHXHGRAEPCAFML-UHFFFAOYSA-N;
CAS number : 1211441-98-3;
Molecule name : LEE-011; LEE 011;
Codes from synonyms : 441;
Origin ID : C95701;
UMLS CUI : C4045494;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
