NCIt definition : An orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic
activity. Roniciclib selectively binds to and inhibits the activity of CDK1/Cyclin
B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that
play key roles in the regulation of the cell cycle progression and cellular proliferation.
Inhibition of these kinases leads to cell cycle arrest during the G1/S transition,
thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.
CDKs are often dysregulated in cancerous cells.;
UNII : 0W9Q8U337A;
InChIKey : UELYDGOOJPRWGF-SRQXXRKNSA-N;
CAS number : 1223498-69-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1223498-69-8
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