" /> Roniciclib - CISMeF





Preferred Label : Roniciclib;

NCIt definition : An orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Roniciclib selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are often dysregulated in cancerous cells.;

UNII : 0W9Q8U337A;

InChIKey : UELYDGOOJPRWGF-SRQXXRKNSA-N;

CAS number : 1223498-69-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1223498-69-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BAY1000394;

NCI Metathesaurus CUI : CL423828;

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14/05/2024


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