Roniciclib - CISMeF

Preferred Label : Roniciclib;

NCIt definition : An orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Roniciclib selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are often dysregulated in cancerous cells.;

UNII : 0W9Q8U337A;

InChIKey : UELYDGOOJPRWGF-SRQXXRKNSA-N;

CAS number : 1223498-69-8;

Molecule name : BAY1000394;

NCI Metathesaurus CUI : CL423828;

Details

Origin ID

C92579;

UMLS CUI

C4054055;

Currated CISMeF NLP mapping
- roniciclib [MeSH concept]
- roniciclib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- roniciclib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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