" /> Cyclin-Dependent Kinase 2 - CISMeF





Preferred Label : Cyclin-Dependent Kinase 2;

NCIt synonyms : p33 Protein Kinase; CDK2; CDC2-Related Protein Kinase; EC 2.7.1.11; p33(CDK2); Cell Division Kinase 2; Cyclin-Dependent Kinase-2; EC 2.7.11.22; Cell Division Protein Kinase 2;

NCIt definition : Cyclin-dependent kinase 2 (298 aa, 34 kDa) is encoded by the human CDK2 gene. This protein is involved in the regulation of both phosphorylation of cyclins and the cell cycle progression from the G2 phase to mitosis.;

NCIt note : This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (LocusLink, OMIM);

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28/05/2025


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