G1 to S Transition Pathway

Preferred Label : G1 to S Transition Pathway;

NCIt related terms : Influence of Ras and Rho proteins on G1 to S Transition;

Alternative definition : BIOCARTA: The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This transition is regulated by the checkpoint kinase cdk2 that activates the G1 to S transition when it is associated with cyclin E. Cdk2/Cyclin E causes the G1 to S transition through phosphorylation of the tumor suppressor Rb, releasing the transcription factor E2F-1. Other pathways acting through Rac, Ras, and Rho also regulate the G1 to S transition. Ras regulates cyclin D1 expression to affect the G1 to S transition. Transforming forms of Ras or Raf induce cyclin D1 expression and cause early entry into S phase. Signaling from Ras to Raf to MEK to ERKs induces Cyclin D1 expression, allowing Cyclin D1 to complex with Cdk4 and Cdk6 and phosphorylate Rb. Rac-1 and PAK appear to induce Cyclin D1 expression and induce the G1 to S transition primarily through activation of NF-kB to activate the Cyclin D1 promoter. Rho activates cdk2 and also inhibits p21 and p27 to induce cyclin D1 and stimulate the G1 to S transition. Rho represses p21 expression to block p21 induction by Ras and to allow Ras induced progression from G1 to S. Cells that lack p21 do not require Rho for Ras to induce cell cycle progression from G1 to S phase. The cooperative action of Ras, Rac and Rho to induce Cyclin D1 expression is a key component of oncogenic transformation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_RacCycDPathway;

Details

Origin ID

C39210;

UMLS CUI

C1517344;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CCNE1 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CDK4 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- CDKN1B wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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