p53 Signaling Pathway BioCarta

Preferred Label : p53 Signaling Pathway BioCarta;

NCIt related terms : p53 Signaling Pathway;

Alternative definition : BIOCARTA: p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to DNA present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_p53Pathway;

Details

Origin ID

C39180;

UMLS CUI

C1515680;

Automatic exact mappings (from CISMeF team)
- DNA damage response, signal transduction by p53 class mediator [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Apoptosis Regulator BAX [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- Metalloproteinase Inhibitor 3 [NCIt concept]
- Proliferating Cell Nuclear Antigen [NCIt concept]
- Protein Mdm4 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
pathway_has_gene_element
- APAF1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CCNE1 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CDK4 wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MDM4 wt Allele [NCIt concept]
- PCNA wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- TIMP3 wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients