MDM4 wt Allele

Preferred Label : MDM4 wt Allele;

NCIt synonyms : Mdm4, Transformed 3T3 Cell Double Minute 4, p53 Binding Protein (Mouse) Gene; DKFZp781B1423; Mouse Double Minute 4, Human Homolog of; p53-Binding Protein Gene; HDMX; MRP1; MDMX; MGC132766; Mouse Double Minute 4 Homolog Gene; Mdm4 p53 Binding Protein Homolog (Mouse) Gene; MDM4, p53 Regulator wt Allele; Double Minute 4, Human Homolog of; p53-Binding Protein Gene;

NCIt definition : Human MDM4 wild-type allele is located in the vicinity of 1q32 and is approximately 34 kb in length. This allele, which encodes protein Mdm4, is involved in cell cycle checkpoint regulation. Aberrant gene expression is associated with retinoblastoma.;

NCIt note : The MDM4 gene may be a therapeutic target for cancers that have an unmutated TP53 gene.;

GenBank Accession Number : AF007111;

Details

Origin ID

C88219;

UMLS CUI

C2981745;

OMIM relation
- Mdm4 regulator of p53 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Retinoblastoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1q32 [NCIt concept]
gene_is_element_in_pathway
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Transcription [NCIt concept]

Keyword's position in hierarchy(ies) :

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