Serine-Protein Kinase ATM

Preferred Label : Serine-Protein Kinase ATM;

NCIt synonyms : Ataxia Telangiectasia Mutated; ATM Protein; AT Mutated; ATM Serine/Threonine Protein Kinase; Ataxia Telangiectasia Protein; ATM; A-T Mutated; Ataxia Telangiectasia Mutated Protein; EC 2.7.11.1;

NCIt definition : Serine-protein kinase ATM (3056 aa, 351 kDa) is encoded by the human ATM gene. This protein is involved in DNA damage-induced protein phosphorylation.;

NCIt note : Serine-protein kinase ATM contains 1 FAT domain, 1 FATC domain and 1 PI3K/PI4K domain. (UniProt);

Details

Origin ID

C17924;

UMLS CUI

C3711796;

Automatic exact mappings (from CISMeF team)
- ATM serine/threonine kinase [ORDO Gene]
- Atm serine/threonine kinase [OMIM gene]
- Atmosphere [LOINC System]
- Mutation [DeCS]
- Mutation [UNESCO concept]
- Mutations [LOINC Class]
- Mutations [LOINC component]
- ataxia telangiectasia mutated proteins [MeSH Descriptor]
- atmosphere (qualifier value) [SNOMED CT concept]
- mutation [MeSH concept]
- mutation [IUPAC Term]
- mutation [MeSH Descriptor]
- mutation [COVID-19 Thesaurus concept]
- mutation [Blood Transfusion thesaurus concept]
- temporomandibular joint [MeSH Descriptor]
Currated CISMeF NLP mapping
- ataxia telangiectasia mutated proteins [MeSH concept]
OMIM relation
- Atm serine/threonine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ATM protein, human [MeSH concept]
- ATM protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ATM Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- ATM Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- BARD1 Signaling Pathway [NCIt concept]
- CDC25 and CHK1 Regulatory Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- p38 MAPK Signaling Pathway PID [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Ataxia Telangiectasia Syndrome [NCIt concept]
- Breast Carcinoma [NCIt concept]
- Leukemia [NCIt concept]
- Lymphoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Repair [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Differentiation [NCIt concept]
is_target
- ATM Inhibitor M 3541 [NCIt concept]
- ATM Kinase Inhibitor AZD1390 [NCIt concept]
- ATM Kinase Inhibitor WSD-0628 [NCIt concept]
- ATM Kinase/DNA-PK Inhibitor XRD-0394 [NCIt concept]
- Lartesertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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