Preferred Label : ATM Kinase Inhibitor AZD1390;
NCIt synonyms : 7-Fluoro-1-isopropyl-3-methyl-8-(6-(3-(piperidin-1-yl)propoxy)pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one;
NCIt related terms : AZD-1390;
NCIt definition : An orally bioavailable inhibitor of ataxia telangiectasia mutated (ATM) kinase, with
potential antineoplastic activity. Upon oral administration, AZD1390 targets and binds
to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling.
This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces
tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells. AZD1390
hypersensitizes tumors to chemo/radiotherapy. In addition, AZD1390 is able to cross
the blood-brain barrier (BBB). ATM, a serine/threonine protein kinase belonging to
the phosphatidylinositol 3-kinase-related kinase (PIKK) family of protein kinases,
is upregulated in a variety of cancer cell types. It is activated in response to DNA
double-strand breaks (DSB) and plays a key role in DNA repair.;
UNII : CI43QFE22O;
CAS number : 2089288-03-7;
Molecule name : AZD-1390;
NCI Metathesaurus CUI : CL552001;
Origin ID : C150167;
UMLS CUI : C4725650;
Semantic type(s)
- UMLS correspondences (same concept)
- AZD1390 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
