T-Cell Differentiation

Preferred Label : T-Cell Differentiation;

NCIt synonyms : T-Cell Development; T-Lymphocyte Development; T-Cell Ontogeny;

NCIt definition : Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP);

Details

Origin ID

C19055;

UMLS CUI

C1515126;

Currated CISMeF NLP mapping
- T cell differentiation [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_anatomy
- T-Lymphocyte [NCIt concept]
biological_process_involves_gene_product
- Calcium Release-Activated Calcium Channel Protein 1 [NCIt concept]
- Dedicator of Cytokinesis Protein 2 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Forkhead Box Protein N1 [NCIt concept]
- Forkhead Box Protein P3 [NCIt concept]
- Interleukin-27 Subunit Alpha [NCIt concept]
- Interleukin-27 Subunit Beta [NCIt concept]
- Interleukin-7 [NCIt concept]
- Lymphocyte Cytosolic Protein 2 [NCIt concept]
- Membrane Cofactor Protein [NCIt concept]
- Myelin and Lymphocyte Protein [NCIt concept]
- Nonhomologous End-Joining Factor 1 [NCIt concept]
- Nuclear Receptor ROR-Gamma T [NCIt concept]
- Paired Box Protein Pax-1 [NCIt concept]
- RAS Guanyl-Releasing Protein 1 [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- T-Cell Differentiation Antigen CD6 [NCIt concept]
- T-Lymphocyte Surface Antigen Ly-9 [NCIt concept]
- Transcription Factor SOX-4 [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 7B [NCIt concept]
biological_process_is_part_of_process
- Histogenic Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Immune System Process [NCIt concept]
process_involves_gene
- ATM Gene [NCIt concept]
- ATM wt Allele [NCIt concept]
- CD46 Gene [NCIt concept]
- CD46 wt Allele [NCIt concept]
- CD6 Gene [NCIt concept]
- CD6 wt Allele [NCIt concept]
- DOCK2 Gene [NCIt concept]
- DOCK2 wt Allele [NCIt concept]
- EBI3 Gene [NCIt concept]
- EBI3 wt Allele [NCIt concept]
- FADD Gene [NCIt concept]
- FADD wt Allele [NCIt concept]
- FOXN1 Gene [NCIt concept]
- FOXN1 wt Allele [NCIt concept]
- IL27 Gene [NCIt concept]
- IL27 wt Allele [NCIt concept]
- IL7 Gene [NCIt concept]
- IL7 wt Allele [NCIt concept]
- LCP2 Gene [NCIt concept]
- LCP2 wt Allele [NCIt concept]
- LY9 Gene [NCIt concept]
- LY9 wt Allele [NCIt concept]
- MAL Gene [NCIt concept]
- MAL wt Allele [NCIt concept]
- NHEJ1 Gene [NCIt concept]
- NHEJ1 wt Allele [NCIt concept]
- ORAI1 Gene [NCIt concept]
- ORAI1 wt Allele [NCIt concept]
- PAX1 Gene [NCIt concept]
- PAX1 wt Allele [NCIt concept]
- RASGRP1 Gene [NCIt concept]
- RASGRP1 wt Allele [NCIt concept]
- SOX4 Gene [NCIt concept]
- SOX4 wt Allele [NCIt concept]
- ZBTB7B Gene [NCIt concept]
- ZBTB7B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients