ATM Signaling Pathway

Preferred Label : ATM Signaling Pathway;

Alternative definition : BIOCARTA: The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_atmPathway;

Details

Origin ID

C38996;

UMLS CUI

C1510698;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- ATR-Interacting Protein [NCIt concept]
- Breast Cancer Type 1 Susceptibility Protein [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 1 [NCIt concept]
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Nibrin [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Protein p73 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- ATRIP wt Allele [NCIt concept]
- BRCA1 wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- CHEK1 wt Allele [NCIt concept]
- CHEK2 wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- NBN wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RAD51 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]
- TP73 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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