CHEK1 wt Allele

Preferred Label : CHEK1 wt Allele;

NCIt synonyms : Cell Cycle Checkpoint Kinase Gene; Checkpoint Kinase 1 wt Allele; Serine/Threonine-Protein Kinase CHK1 Gene; CHK1; CHK1 Checkpoint Homolog (S. pombe) Gene; Checkpoint, S. pombe, Homolog of Gene; CHK1 (Checkpoint, S. pombe) Homolog Gene;

NCIt definition : Human CHEK1 wild-type allele is located within 11q24-q24 and is approximately 29 kb in length. This allele, which encodes serine/threonine-protein kinase Chk1 protein, plays a role in the induction of cell cycle arrest at the G2/M checkpoint in response to either DNA damage or the presence of unreplicated DNA.;

GenBank Accession Number : NM_001274;

Details

Origin ID

C51196;

UMLS CUI

C1707128;

Automatic exact mappings (from CISMeF team)
- Checkpoint kinase 1 [OMIM gene]
OMIM relation
- Checkpoint kinase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 11: 125001547-125030847 [NCIt concept]
gene_in_chromosomal_location
- 11q24-q24 [NCIt concept]
gene_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- CDC25 and CHK1 Regulatory Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- Circadian Rhythm Pathway PID [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Negative Regulation of Cell Cycle [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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