Preferred Label : RB Checkpoint Signaling Pathway;
NCIt related terms : RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage;
Alternative definition : BIOCARTA: Cell cycle checkpoint controls at the G1 to S transition and the G2 to M
transition prevent the cell cycle from progressing when DNA is damaged. The ATM protein
kinase detects DNA damage and, in response to this, activates DNA repair factors and
inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response
to DNA damage are the tumor suppressor p53 and the checkpoint kinase chk1. In turn,
the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin
dependent kinase 2) preventing passage from G1 to S phase and harmful replication
of damaged DNA. One of the targets of cdk2 is the Rb gene product, another tumor suppressor.
When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription
of genes required for progression through the cell cycle. When phosphorylated by cell
cycle dependent kinases like cdk2 and cdk4, Rb no longer interacts with E2F and the
cell cycle proceeds through the G1-S checkpoint. DNA damage also regulates the G2-M
phase transition by acting on the cell cycle regulator cdc2. (This definition may
be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_rbPathway;
Origin ID : C39218;
UMLS CUI : C1514642;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
