Cyclin-Dependent Kinase 1

Preferred Label : Cyclin-Dependent Kinase 1;

NCIt synonyms : EC 2.7.11.23; p34(CDC2); Cell Division Cycle 2 Protein; Cyclin-Dependent Kinase-1; CDC2; Cell Division Cycle 2; EC 2.7.11.22; p34 Protein Kinase; p34CDC2; CDK1; Cell Cycle Controller cdc2; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1;

NCIt definition : Cyclin-dependent kinase 1 (297 aa, 34 kDa) is encoded by the human CDK1 gene. This protein is involved in protein phosphorylation and cell cycle regulation.;

NCIt note : A serine/threonine protein kinase subunit of the M-phase promoting factor complex, required for entry into S-phase and mitosis. A member of the CDC2/CDKX subfamily, p34(cdc2) forms a complex with a Cyclin, and phosphorylates RNA Polymerase II. CDC2 gene expression is transcriptionally regulated and phosphorylation regulates cdc2 activity.;

Details

Origin ID

C17386;

UMLS CUI

C2353787;

OMIM relation
- Cyclin-dependent kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDC2 protein kinase [MeSH concept]
- CDC2 protein kinase [MeSH Descriptor]
- CDK1 protein, human [MeSH Supplementary Concept]
- CDK1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDK1 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_is_element_in_pathway
- AKAP8 in Mitosis Pathway [NCIt concept]
- CDC25 and CHK1 Regulatory Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Centrosome Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- Oocyte Maturation Pathway [NCIt concept]
- Ptc1 Regulation of Cell Cycle Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- SRC Tyrosine Kinase Activation Pathway [NCIt concept]
- Splicing Regulation Pathway [NCIt concept]
- Stathmin Pathway [NCIt concept]
gene_product_is_physical_part_of
- M-Phase Promoting Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- CDK Inhibitor R547 [NCIt concept]
- CDK1/2/4 Inhibitor AG-024322 [NCIt concept]
- Dinaciclib [NCIt concept]
- Riviciclib [NCIt concept]
- Riviciclib Hydrochloride [NCIt concept]
- Roniciclib [NCIt concept]
- Zotiraciclib Citrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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