Riviciclib - CISMeF

Preferred Label : Riviciclib;

NCIt synonyms : Cyclin Dependent Kinase Inhibitor P276; P-276-00 Free Base;

NCIt definition : A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Riviciclib selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.;

UNII : 9EK26WE8QN;

InChIKey : QLUYMIVVAYRECT-GXTWGEPZSA-N;

CAS number : 920113-02-6;

Molecule name : P276-00; P276;

Details

Origin ID

C64762;

UMLS CUI

C4688384;

Automatic exact mappings (from CISMeF team)
- riviciclib [MeSH concept]
- riviciclib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- riviciclib [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Riviciclib Hydrochloride [NCIt concept]
has_target
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 9 [NCIt concept]
is_free_acid_or_base_form_of
- Riviciclib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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