NCIt definition : The hydrochloride salt form of riviciclib, a flavone and cyclin dependent kinase (CDK)
inhibitor with potential antineoplastic activity. Riviciclib selectively binds to
and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases
that play key roles in the regulation of the cell cycle and cellular proliferation.
Inhibition of these kinases leads to cell cycle arrest during the G1/S transition,
thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.;
UNII : DRP53ZDY6H;
InChIKey : OOVTUOCTLAERQD-OJMBIDBESA-N;
CAS number : 920113-03-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 920113-03-7
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Semantic type(s)