M-Phase Promoting Factor

Preferred Label : M-Phase Promoting Factor;

NCIt synonyms : MPF; Mitosis-Promoting Factor; Maturation-Promoting Factor; Mitosis Promoting Factor; Maturation Promoting Factor; M Phase-Promoting Factor; M-Phase-Promoting Factor;

NCIt definition : M Phase-Promoting Factor is a protein kinase complex that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.;

NCIt note : M-phase promoting factor is a heterodimer of the serine/threonine protein kinase cyclin-dependent kinase 1 with cyclin b.;

Details

Origin ID

C28557;

UMLS CUI

C0079805;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Maturation-Promoting factor [MeSH concept]
- Maturation-Promoting factor [MeSH Descriptor]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromosome Condensation [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- G2 to M Transition Process [NCIt concept]
- Meiosis [NCIt concept]
has_gene_product_element
- Cyclin B [NCIt concept]
- Cyclin-Dependent Kinase 1 [NCIt concept]
- G2/Mitotic-Specific Cyclin-B1 [NCIt concept]
- G2/Mitotic-Specific Cyclin-B2 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients