Preferred Label : Maturation-Promoting factor;
MeSH definition : Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms.
In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it
has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates
some of the proteins involved in nuclear envelope breakdown, chromosome condensation,
spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is
PROTEIN P34CDC2.;
MeSH synonym : mitosis-promoting factor; m phase-promoting factor; histone h1 kinase, m phase specific; histone h1 kinase, growth-associated; mitosis promoting factor; m phase promoting factor; histone h1 kinase, growth associated; histone h1 kinase, m-phase-specific; maturation promoting factor;
CISMeF synonym : EC 2.7.1.37;
Registry Number MeSH : EC 2.7.11.22;
MeSH annotation : DF: MPF;
Is substance : O;
UNII : EC 2.7.11.22;
Origin ID : D016200;
UMLS CUI : C0079805;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms.
In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it
has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates
some of the proteins involved in nuclear envelope breakdown, chromosome condensation,
spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is
PROTEIN P34CDC2.
