Cyclin-Dependent Kinase 8

Preferred Label : Cyclin-Dependent Kinase 8;

NCIt synonyms : EC 2.7.11.23; Protein Kinase K35; Mediator of RNA Polymerase II Transcription Subunit CDK8; Mediator Complex Subunit CDK8; EC 2.7.11.22; Cell Division Protein Kinase 8; CDK8;

NCIt definition : Cyclin-dependent kinase 8 (464 aa, 53 kDa) is encoded by the human CDK8 gene. This protein plays a role in the modulation of both transcription and protein phosphorylation.;

Details

Origin ID

C95299;

UMLS CUI

C1384564;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase 8 [MeSH Descriptor]
- Cyclin-Dependent kinase 8 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK8 protein, human [MeSH concept]
- CDK8 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CDK8 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Mediator Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084 [NCIt concept]

Keyword's position in hierarchy(ies) :

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