Preferred Label : Mediator Complex;
NCIt synonyms : Mediator of RNA Polymerase II Transcription; Mediator Coactivator Complex; Mediator Coactivator; Mediator; Mediator of Activation;
NCIt definition : A protein complex that is involved in the initiation of transcription. This complex
is composed of over 30 protein subunits, which binds to the RNA polymerase II holoenzyme
complex and facilitates the interaction of transcription factors with the polymerase.;
NCIt note : The human Mediator complex is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10,
MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11.
(UniProt);
Origin ID : C19864;
UMLS CUI : C1363844;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_plays_role_in_biological_process
- has_gene_product_element
