mediator complex

Preferred Label : mediator complex;

MeSH definition : A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.;

MeSH synonym : mediator transcription complex;

Wikipedia automatic translation : Mediator (coactivator);

MeSH hyponym : Mediator-Like complexes; thyroid Hormone-Associated protein complex; Thyroid Hormone Associated Protein Complex; TRAP (Thyroid Hormone Associated Protein) Complex; TR-Associated Protein (TRAP) Complex; Mediator Like Complexes; Mediator-Like Complex; Mediator Like Complex;

Wikipedia link : https://en.wikipedia.org/wiki/Mediator (coactivator);

Is substance : O;

Details

Origin ID

D056892;

UMLS CUI

C2919060;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- TRAP Complex [NCIt concept]
- TRAPP complex [GO term]
- mediator complex [GO term]
Currated CISMeF NLP mapping
- Mediator Complex [NCIt concept]
Indexing information
- MDT-15 protein, C elegans [MeSH Supplementary Concept]
Record concept(s)
- Mediator-Like complexes [MeSH concept]
- mediator complex [MeSH concept]
- thyroid Hormone-Associated protein complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- AT5G12230 protein, Arabidopsis [MeSH Supplementary Concept]
- CSE2 protein, S cerevisiae [MeSH Supplementary Concept]
- DRIP, VDR interacting protein complex [MeSH Supplementary Concept]
- GAL11 protein, S cerevisiae [MeSH Supplementary Concept]
- MDT-28 protein, C elegans [MeSH Supplementary Concept]
- MED10 protein, human [MeSH Supplementary Concept]
- MED11 protein, human [MeSH Supplementary Concept]
- MED12 protein, human [MeSH Supplementary Concept]
- MED13 protein, human [MeSH Supplementary Concept]
- MED13L protein, human [MeSH Supplementary Concept]
- MED14 protein, human [MeSH Supplementary Concept]
- MED15 protein, human [MeSH Supplementary Concept]
- MED16 protein, human [MeSH Supplementary Concept]
- MED16 protein, mouse [MeSH Supplementary Concept]
- MED17 protein, drosophila [MeSH Supplementary Concept]
- MED18 protein, arabidopsis [MeSH Supplementary Concept]
- MED19 protein, human [MeSH Supplementary Concept]
- MED2 protein, Arabidopsis [MeSH Supplementary Concept]
- MED2 protein, S cerevisiae [MeSH Supplementary Concept]
- MED20 protein, Arabidopsis [MeSH Supplementary Concept]
- MED21 protein, human [MeSH Supplementary Concept]
- MED22 protein, human [MeSH Supplementary Concept]
- MED23 protein, human [MeSH Supplementary Concept]
- MED24 protein, human [MeSH Supplementary Concept]
- MED25 protein, human [MeSH Supplementary Concept]
- MED26 protein, human [MeSH Supplementary Concept]
- MED27 protein, human [MeSH Supplementary Concept]
- MED28 protein, Arabidopsis [MeSH Supplementary Concept]
- MED28 protein, human [MeSH Supplementary Concept]
- MED29 protein, human [MeSH Supplementary Concept]
- MED30 protein, human [MeSH Supplementary Concept]
- MED31 protein, human [MeSH Supplementary Concept]
- MED31 protein, mouse [MeSH Supplementary Concept]
- MED4 protein, human [MeSH Supplementary Concept]
- MED6 protein, S cerevisiae [MeSH Supplementary Concept]
- MED6 protein, human [MeSH Supplementary Concept]
- MED7 protein, S cerevisiae [MeSH Supplementary Concept]
- MED7 protein, human [MeSH Supplementary Concept]
- MED8 protein, Arabidopsis [MeSH Supplementary Concept]
- MED8 protein, S cerevisiae [MeSH Supplementary Concept]
- MED8 protein, human [MeSH Supplementary Concept]
- MED8 protein, rat [MeSH Supplementary Concept]
- Med11 protein, S cerevisiae [MeSH Supplementary Concept]
- Med12 protein, mouse [MeSH Supplementary Concept]
- Med12 protein, zebrafish [MeSH Supplementary Concept]
- Med13 protein, mouse [MeSH Supplementary Concept]
- Med13l protein, mouse [MeSH Supplementary Concept]
- Med14 protein, S pombe [MeSH Supplementary Concept]
- Med14 protein, zebrafish [MeSH Supplementary Concept]
- Med17 protein, human [MeSH Supplementary Concept]
- Med20 protein, mouse [MeSH Supplementary Concept]
- Med22 protein, Drosophila [MeSH Supplementary Concept]
- Med23 protein, mouse [MeSH Supplementary Concept]
- Med24 protein, mouse [MeSH Supplementary Concept]
- Med25 protein, mouse [MeSH Supplementary Concept]
- Med27 protein, zebrafish [MeSH Supplementary Concept]
- Med28 protein, mouse [MeSH Supplementary Concept]
- Med30 protein, mouse [MeSH Supplementary Concept]
- Med31 protein, drosophila [MeSH Supplementary Concept]
- Med6 protein, S pombe [MeSH Supplementary Concept]
- Med6 protein, drosophila [MeSH Supplementary Concept]
- NUT1 protein, S cerevisiae [MeSH Supplementary Concept]
- NUT2 protein, S cerevisiae [MeSH Supplementary Concept]
- PGD1 protein, S cerevisiae [MeSH Supplementary Concept]
- RGR1 protein, S cerevisiae [MeSH Supplementary Concept]
- ROX3 protein, S cerevisiae [MeSH Supplementary Concept]
- SIN4 protein, S cerevisiae [MeSH Supplementary Concept]
- SOH1 protein, S cerevisiae [MeSH Supplementary Concept]
- SRB2 protein, S cerevisiae [MeSH Supplementary Concept]
- SRB4 protein, S cerevisiae [MeSH Supplementary Concept]
- SRB5 protein, S cerevisiae [MeSH Supplementary Concept]
- SRB6 protein, S cerevisiae [MeSH Supplementary Concept]
- SRB7 protein, S cerevisiae [MeSH Supplementary Concept]
- SSN2 protein, S cerevisiae [MeSH Supplementary Concept]
- TNRC6c protein, mouse [MeSH Supplementary Concept]
- pmc4 protein, S pombe [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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