TRAP Complex - CISMeF

Preferred Label : TRAP Complex;

NCIt synonyms : TRAP Mediator Complex; Thyroid Hormone Receptor-Associated Protein Complex; TRAP/Mediator Complex; TRAP Mediator;

NCIt definition : The human thyroid hormone receptor-associated protein (TRAP)-Mediator complex was originally identified as a large multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa cells and markedly enhances TR-mediated transcription in vitro. More recent studies have implicated TRAP-Mediator as a coactivator for a broad range of nuclear hormone receptors as well as other classes of transcriptional activators. TRAP-Mediator may play an important coregulatory role in androgen receptor-mediated gene expression. (from J Biol Chem. 2002;277:42852-8);

Details

Origin ID

C19890;

UMLS CUI

C1336668;

Automatic exact mappings (from CISMeF team)
- TRAPP complex [GO term]
- mediator complex [GO term]
- mediator complex [MeSH Descriptor]
- thyroid Hormone-Associated protein complex [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Mediator Complex Component Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Coactivator [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcription Initiation [NCIt concept]
- Transcriptional Activation [NCIt concept]
has_gene_product_element
- Thyroid Hormone Receptor-Associated Protein 3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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