Preferred Label : c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084;
NCIt synonyms : Protein Kinase Inhibitor TSN084; Multiple Kinase Inhibitor TSN084;
NCIt related terms : TSN-084;
NCIt definition : An orally bioavailable type II protein kinase inhibitor of multiple kinases, including
c-Met (hepatocyte growth factor receptor; HGFR), FMS-like tyrosine kinase-3 (FLT3;
CD135; fetal liver kinase-2; Flk2), tropomyosin-related-kinase (tyrosine receptor
kinase; TRK), and cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic
and immunomodulating activities. Upon oral administration, c-Met/FLT3/TRK/CDK8/19
inhibitor TSN084 targets, binds to and inhibits the activity of various kinases, such
as c-Met, FLT3, TRK and CDK8/19, and prevents activation of oncogenic signaling pathways
mediated by these kinases, blocks selective transcription of various tumor-promoting
genes, and inhibits proliferation of susceptible tumor cells that overexpress these
kinases. These kinases are overexpressed or mutated in certain cancer cell types and
play key roles in tumor cell proliferation, survival, invasion, treatment resistance
and immune evasion.;
UNII : 9FJ3MBL7XW;
CAS number : 2412309-60-3;
Molecule name : TSN-084; TSN 084;
NCI Metathesaurus CUI : CL1792200;
Origin ID : C187375;
UMLS CUI : C5706418;
Semantic type(s)
- concept_is_in_subset
- has_target
