Preferred Label : High Affinity Nerve Growth Factor Receptor;
NCIt synonyms : Nerve Growth Factor Receptor Type 1; NTRK1; Tyrosine Kinase Receptor; EC 2.7.10.1; Tyrosine Kinase Receptor A; Tropomyosin-Related Kinase A; TRK1-Transforming Tyrosine Kinase Protein; gp140trk; Trk-A; p140-TrkA; Neurotrophic Tyrosine Kinase Receptor Type 1; Neurotrophic Tyrosine Kinase Receptor Type-1; TrkA;
NCIt definition : High affinity nerve growth factor receptor (796 aa, 87 kDa) is encoded by the human
NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and
receptor-mediated signaling.;
NCIt note : NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers
with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate
development and function of the nociceptive and thermoregulatory nervous systems.
Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1,
and ERK1 signaling pathways.;
NCI Metathesaurus CUI : CL1648602;
Origin ID : C28558;
UMLS CUI : C3853565;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_gene_product_variant
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
- is_target
