Preferred Label : Pan-TRK Inhibitor ONO-7579;
NCIt synonyms : TRK Inhibitor ONO-7579;
NCIt definition : An orally bioavailable, selective pan-tropomyosin-related-kinase (tyrosine receptor
kinase; TRK) inhibitor, with potential antineoplastic activity. Upon oral administration,
ONO-7579 specifically targets and binds to TRK and fusion proteins containing sequences
from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2;
TrkB), and 3 (NTRK3; TrkC). This inhibits neurotrophin-TRK interaction and TRK activation,
thereby preventing the activation of downstream signaling pathways and resulting in
both the induction of cellular apoptosis and the inhibition of cell growth in tumors
that overexpress TRK and/or express NTRK fusion proteins. TRK, a family of receptor
tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes.The
expression of either mutated forms of, or fusion proteins involving, NTRK family members
results in uncontrolled TRK signaling, which plays an important role in tumor cell
growth, survival, invasion and treatment resistance.;
Molecule name : ONO-7579; ONO 7579;
NCI Metathesaurus CUI : CL538536;
Origin ID : C140379;
UMLS CUI : C4682896;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
