Preferred Label : Repotrectinib;
NCIt synonyms : Multikinase Inhibitor TPX-0005; Multi-kinase Inhibitor TPX-0005; ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005;
NCIt definition : An orally available inhibitor of multiple kinases, including the receptor tyrosine
kinase anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), the neurotrophic
tyrosine receptor kinase (NTRK) types 1, 2 and 3, the proto-oncogene SRC, and focal
adhesion kinase (FAK), with potential antineoplastic activity. Upon oral administration,
repotrectinib binds to and inhibits wild-type, point mutants and fusion proteins of
ALK, ROS1, NTRK1-3, SRC, FAK and, to a lesser extent, other kinases. Inhibition of
these kinases leads to the disruption of downstream signaling pathways and the inhibition
of cell growth of tumors in which these kinases are overexpressed, rearranged or mutated.;
UNII : 08O3FQ4UNP;
InChIKey : FIKPXCOQUIZNHB-WDEREUQCSA-N;
CAS number : 1802220-02-5;
Drug name : Augtyro;
Molecule name : TPX-0005; TPX 0005;
NCI Metathesaurus CUI : CL521742;
Codes from synonyms : 136156;
Origin ID : C133821;
UMLS CUI : C4524909;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
